Prevalence of Hepatotoxicity From Antituberculosis Therapy
نویسندگان
چکیده
منابع مشابه
Antituberculosis drugs and hepatotoxicity.
Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...
متن کاملAn official ATS statement: hepatotoxicity of antituberculosis therapy.
Drug-induced liver injury (DILI) is a problem of increasing significance, but has been a long-standing concern in the treatment of tuberculosis (TB) infection. The liver has a central role in drug metabolism and detoxification, and is consequently vulnerable to injury. The pathogenesis and types of DILI are presented, ranging from hepatic adaptation to hepatocellular injury. Knowledge of the me...
متن کاملHepatotoxicity and antituberculosis therapy: time to revise UK guidance?
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متن کاملAntituberculosis treAtment-induced HepAtotoxicity: From bencH to bedside
commonly encountered adverse effect withantituberculosis treatment.6-8 Recent developments especially in the field of molecular biology have expanded our views on the understanding of drug-induced liver damage. 9,10 In this paper, we have attempted to summarise the current understanding of the pathogenetic mechanismsof DIH as it has been viewed from the laboratory bench and the bedsideimplicati...
متن کاملAntituberculosis drug-induced hepatotoxicity in children
Recent increases in the dosages of the essential antituberculosis agents isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) for use in children recommended by World Health Organization have raised concerns regarding the risk of hepatotoxicity. Published data relating to the incidence and pathogenesis of antituberculosis drug-induced hepatotoxicity (ADIH), particularly in children, is reviewe...
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ژورنال
عنوان ژورنال: Journal of Primary Care & Community Health
سال: 2016
ISSN: 2150-1327,2150-1327
DOI: 10.1177/2150131916642431